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|CAS NO.:||401900-40-1||Purity:||99% By HPLC|
|Quality Standard:||USP/BP/ISO9001||Appearance:||White Powder|
Tamoxifen Citrate Nolvadex 54965-24-1,
99% Assay Tamoxifen Citrate Nolvadex
99% Assay Tamoxifen Citrate Nolvadex 54965-24-1 Muscle Gaining USP Standard
|Product name||Tamoxifen citrate|
|CAS register number||54965-24-1|
|Melting point||140-144 °C|
|Minimum order quantity||10gram|
|Appearance||White crystalline powder|
Tamoxifen is a nonsteroidal anti-estrogen drug. The structures are similar to those of estrogens, and are present in type Z and type O isoforms. The physical and chemical properties are different from each other, and their physiological activities are different. Type E has weak estrogenic activity, and type Z has an anti estrogenic effect. If estrogen receptor (ER) is present in breast cancer cells, estrogen enters tumor cells and combines with ER to promote tumor cell mRNA and DNA synthesis and stimulate tumor cell growth. However, the tamoxifen Z isoform enters the cell and competes with ER to form a receptor complex that inhibits estrogen and inhibits proliferation of breast cancer cells.
Mainly used for the treatment of breast cancer patients with high levels of estrogen, androgen and other anticancer drugs (such as more flexible than the magnitude) combined to improve postmenopausal advanced breast cancer patients after curative effect and shows good curative effect.
Nolvadex is the trade name for the drug tamoxifen citrate, it is a non-steroidal agent that demonstrates potent anti-estrogenic properties. The drug is technically an estrogen agonist/antagonist, which competitively binds to estrogen receptors in various target tissues. With the tamoxifen molecule bound to this receptor, estrogen is blocked from exerting any action, and an anti-estrogenic effect is achieved.
Since many forms of breast cancer are responsive to estrogen, the ability of tamoxifen citrate to block its action in such cells has proven to be a very effective treatment. It is also utilized successfully as a preventative measure, taken by people with an extremely high familial tendency for breast cancer. While Nolvadex is effective against estrogen, it is not our strongest available remedy.
Nolvadex is an estrogen agonist in the liver, capable of activating the estrogen receptor and mimicking the
actions of this sex hormone in this region of the body. As such it can have a markedly positive impact on
HDL (good) cholesterol values, as does estrogen.
|Items of analysis||Specification||Results|
|Appearance||White to almost white crystalline hygroscopic powder||White powder|
|Identification||A: IR absorption B: Thin-layer chromatographic identification test||Conforms|
|Loss of drying||Should conform to the standard||Conform|
|Melting range||NMT 1.0%||0.35%|
|Heavy metals||164 ºC -168 ºC||165.4-166.5ºC|
|Acidity or alkalinity:||NMT 20ppm||<20ppm|
|Residue on ignition||NMT 0.1%||0.05%|
|Chromatographic||Total impurities: NMT2.0%||Conforms|
|Solution clarity||Meet the requirement(CP Standard)||Conforms|
|Assay||Not less than 98.0% and not more than 102.0%||99.47%|
Wuhan Disel Biotechnoloy Co., Ltd. (shorted as Disel Biotech) is located in Wuhan Donghu High-Tech Economic Development Zone,Disel Biotech is a modern advanced enterprise specializing in production and exportation of APIs, steroid raw powders, peptides, plant extracts etc., has invested and closed cooperated with domestic manufacturers qualified with GMP and Laboratories from famous Universities to meet the different customers' needs from grams to tonnage quantity, which makes Disel Biotech to be more flexible and easily to supply highly cost-effective products with high quality and better service to customers. Disel Biotech is always stands in high starting, high stand and high quality, and masters strict management for production procedure and quality control. We sincerely welcome new and old customers home and abroad to contact us for future business relationships and mutual success!
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